By John S. Bradley MD, John D. Nelson MD Emeritus

ISBN-10: 1581104294

ISBN-13: 9781581104295

This best-selling and ordinary source on pediatric antimicrobial treatment offers rapid entry to trustworthy, up to the moment concepts for therapy of all infectious illnesses in little ones. for every sickness, the authors offer a statement to aid well-being care services decide upon the simplest of all antimicrobial offerings. Drug descriptions hide all antimicrobial brokers on hand this present day and contain whole information regarding dosing regimens. according to becoming issues approximately overuse of antibiotics, this system comprises guidance on while to not prescribe antimicrobials. Key gains: designed if you look after youngsters and are confronted with judgements each day; contains remedy of parasitic infections and tropical drugs; up to date anti-infective drug directory, entire with formulations and dosages; and balanced info on security, efficacy, and tolerability with facts on expenses and availability of drugs.

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Additional info for 2010-2011 Nelson's Pocket Book of Pediatric Antimicrobial Therapy

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Indd 32 Standard: cephalexin 50–75 mg/kg/day PO div tid OR For topical therapy if mild infection: mupirocin or Bullous impetigo1–3,5–7 (usually S aureus, including cloxacillin 50 mg/kg/day PO div qid OR amox/clav retapamulin ointment CA-MRSA) 45 mg/kg/day PO div tid (CII) CA-MRSA: clindamycin 30 mg/kg/day PO div tid OR TMP/SMX 8 mg/kg/day of TMP PO div bid; x 5–7 d (CIII) Bites, animal and human1,15–17 Amox/clav 45 mg/kg/day PO div tid (amox/clav 7:1, Consider rabies prophylaxis for animal bites (AI); consider Pasteurella multocida (animal), see Chapter 1, Aminopenicillins) x 5–10 d (AII); for tetanus prophylaxis Eikenella corrodens (human), hospitalized children, use ticar/clav 200 mg ticarcillin/ Human bites have a very high rate of infection (do not Staphylococcus spp and kg/day div q6h OR ampicillin and clindamycin (BII) close open wounds) Streptococcus spp S aureus coverage is only fair with amox/clav, ticar/clav, pip/tazo.

Renal, bladder ultrasound for fungus ball. Other triazoles are alternatives; insufficient data on echinocandins for neonatal urinary tract infection. – Coliform bacteria Cefotaxime IV, IM OR, in the absence of renal or perinephric (eg, E coli, Klebsiella, abscess, gentamicin IV, IM x 7–10 d (AII) Enterobacter, Serratia) Ampicillin IV, IM X 7–10 days, add gentamicin until cultures are sterile (AIII); for ampicillin resistance, use vancomycin, add gentamicin until cultures are sterile Ceftazidime IV, IM OR, in the absence of renal or perinephric abscess, tobramycin IV, IM x 10 d (AIII) Amphotericin IV OR fluconazole (if susceptible) (AII) – Enterococcus – P aeruginosa – Candida spp33–36 Investigate for kidney disease and for abnormalities of urinary tract Oral therapy for E coli acceptable once infant asymptomatic and culture sterile.

For serious infections, In children with open fractures secondary to trauma, add infection (usually S aureus, ADD cefazolin to provide better MSSA coverage and ceftazidime for extended aerobic gram-negative activity including CA-MRSA; group add Kingella coverage (CIII) Kingella is often resistant to clindamycin A streptococcus; K kingae) For CA-MRSA: clindamycin 30 mg/kg/day IV div q8h or For MSSA (BI) and Kingella (BIII), follow-up oral therapy vancomycin 40 mg/kg/day IV q8h (BII) with cephalexin 100 mg/kg/day PO div tid For MSSA: oxacillin 150 mg/kg/day IV div q6h OR Oral therapy alternatives for CA-MRSA include cefazolin 100 mg/kg/day IV div q8h (AII) clindamycin and linezolid40 For Kingella: cefazolin, ampicillin or ceftriaxone 50 mg/kg/day IV, IM q24h (BIII) Total therapy (IV plus PO) for 4–6 wks for MSSA.

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2010-2011 Nelson's Pocket Book of Pediatric Antimicrobial Therapy by John S. Bradley MD, John D. Nelson MD Emeritus

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